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[138] Fornell et expkry. Syntaxins, in vivo (LD50 tests), 78, 79 acute toxicology teststesting, in vivo (LD50 tests), 8182 exposure routes, 1517 local versus systemic effects, 14 Organ culture embryotoxicitywhole embryo culture, 121 reproductive toxicity, 233234 reproductive toxicity testing, 230 Organelles acute timmes testing endpoints, 175 basal cytotoxicology, 175 cultured cells, toxicity indicators, 155 isolated, 148 Organizational cytotoxicity, 284 Organization for Economic Cooperation and Development (OECD) alternative model applications, 275276 eye test standards, 108 genetic toxicology test standardization, 223, 224 reproductive toxicity test guidelines, 121122 skin tests, 105 Organ-specific cytotoxicity classification based on in vitro methodologies, 283284 functional classification ck if this is ORGAN?, 281 Osmolality, cell culture methodology, 163164 Ovaries, organ culture, 233 Oxidative-reductive reaction systems, biotransformation, 3940 P Pain measurement, chronic toxicity experiments, 95 Paraffin (mineral oil) overlay, 249250 Parametric calculations, 252253 Parenteral exposure exposure routes, 1718 local versus systemic effects, 14 Passaging (subculturing), cultured cells, 153154 Pathology, LD50 tests, 8283 Perfusion cell systems, 165166 Perinatal studies, animal tests, 68 Pesticides, 7, 118 pH cell culture methodology, 162 chronic toxicity, 91 Henderson-Hasselbach equation, 3032 ionic and non-ionic principles, 30 and urinary excretion, 40 Pharmaceuticals, see Drugspharmaceuticals Pharmacokinetics, see also Toxicokinetics chronic 03sec experiments, in vivo, 92 relationship to toxicokinetics, 27 and teratogenicity, 116 PHH (public health hazard), 98 Phocomelia, 112 Photoallergic and phototoxic reactions dermal toxicity testing, 105107, 198, 199200 validation of 3T3 neutral red uptake test, 279 Photolithography, 240 Physiological compartments accumulation of chemicals, 1920 toxicokinetics one-compartment model, 2728 two-compartment model, 28 Brokefs pin printing, 240241 Pilot studies, chronic toxicity experiments in vivo, 92 Pin-based printing, 240 pKM101, 211 Placenta distribution, 38 first trimester events, 113114 maternal-fetal circulation, 114115 Plasma, fluid compartments, 34 Plasma half-life, 90 Plasma protein binding, 35, 37 Plasmid, S.

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These experiments (with embryonic cells of the newt) gave the striking results shown in Figure 20.

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